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. Author manuscript; available in PMC: 2024 Oct 3.
Published in final edited form as: Sci Transl Med. 2023 Feb 8;15(682):eabn5993. doi: 10.1126/scitranslmed.abn5993

Fig. 4. Antibody-mediated NK cell degranulation is associated with clinical protection in a prospective cohort study in Kenyan children.

Fig. 4

(A) Comparison of Ab-NK cell degranulation (left) and IFN-γ production (right) in Junju children over or under 5 years of age. (B) Ab-NK response in children who had an active P. falciparum infection compared with those without. Error bars represent 95% CI of the median values; Mann-Whitney test (n = 293). (C) Antibody-mediated NK cell degranulation (left) and IFN-γ production (right) were correlated with the breadth of total IgG responses against recombinant MSP2, MSP3, and/or AMA-1. Error bars represent 95% CI of the median values; Kruskal-Wallis test with Dunn’s multiple comparisons test (n = 293). (D) Ab-NK cell degranulation and IFN-γ production were associated with clinical protection against symptomatic malaria in children. Ab-NK responses were categorized as high or low (blue) on the basis of a threshold (28); log-rank test, P = 0.001 (n = 293). Each dot represents a technical replicate.