Table 1. Current and planned clinical trials in tuberculous meningitis.
| # | Trial | N | Enrolment Status | Estimated Completion | Registration | Population | Intervention |
|---|---|---|---|---|---|---|---|
| 1 | ACT TBM | 237 | 100% | Complete | CTRI/2019/08/020488 | Adults | ASA or CLOPI or standard care |
| 2 | SIMPLE | 36 | 100% | Complete | NCT03537495 | Adult | High dose RIF + LZD |
| 3 | ALTER | 40 | 100% | Complete, unpublished | NCT04021121 | Adults | High or standard dose RIF + LZD |
| 4 | LAST ACT | 720 | 100% | Mar 2024 | NCT03100786 | HIV- Adults | Corticosteroids stratified by LTA4H genotype |
| 5 | HARVEST | 500 | 53% | Nov 2024 | ISRCTN15668391 | Adults | High dose RIF |
| 6 | INTENSE TBM | 768 | 43% | Aug 2025 | NCT04145258 | Adults, >15yo | High dose RIF+LZD +/-ASA |
| 7 | TIMPANI | 130 | 0% | Dec 2025 | NCT05590455 | HIV+ Adults | Adalimumab (TNF inhibitor) |
| 8 | SURE | 400 | 80% | Dec 2025 | ISRCTN40829906 | Children + adolescents | High dose RIF and INH + LFX w/ or w/o ASA |
| 9 | IMAGINE TBM | 330 | 5% | Feb 2027 | NCT05383742 | Adults, >15yo | High dose RIF and INH + LZD x 6 mos. |
| 10 | INSHORT | 372 | 0% | Sept 2027 | NCT05917340 | Adults | High dose RIF + moxifloxacin + ASA x 6 mos. |
Short form titles or descriptions: ACT TBM = A Randomised Trial to Assess the efficacy or add on therapy with Aspirin or Clopidogrel to the standard medical therapy alone in patients with Tuberculous meningitis. SIMPLE = Pharmacokinetic Study of Linezolid for TB Meningitis. ALTER = Adjunctive Linezolid for the Treatment of Tuberculous Meningitis. LAST ACT = Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults with Tuberculous Meningitis. TIMPANI = TNF Inhibitors to Reduce Mortality in HIV-1 Infected Patients with Tuberculous meningitis. HARVEST = High-dose oral rifampicin to improve survival from adult tuberculous meningitis. INTENSE-TBM = Intensified Tuberculosis Treatment to Reduce the Mortality of Patients with Tuberculous Meningitis. SURE = Short intensive treatment for children with tuberculous meningitis. IMAGINE-TBM = Improved Management with Antimicrobial Agents Isoniazid Rifampicin Linezolid for TBM. HDH Trial = Optimizing Antituberculosis Therapy in Adults with Tuberculous Meningitis. ASA=aspirin. CLOPI=clopidogrel. HIV=human immunodeficiency virus. INH=isoniazid. LTA4H=leukotriene A4 hydrolase. LFX=levofloxacin. LZD=linezolid. NAT-2. N-acetyltransferease-2. RIF=rifampicin. TNF=tumour necrosis factor.