Note: EMS denotes emergency medical service; CPR denotes cardiopulmonary resuscitation. Subgroup analyses adjusted for age, sex, witnessed, bystander CPR, initial rhythm, time from emergency call to drug administration (time from EMS arrival at scene to drug administration for time from call to EMS arrival analysis), etiology of cardiac arrest where applicable. Confidence interval widths have not been adjusted for multiplicity and may not be used in place of hypothesis testing.