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. Author manuscript; available in PMC: 2024 Nov 6.
Published in final edited form as: J Biotechnol. 2024 Oct 10;396:1–9. doi: 10.1016/j.jbiotec.2024.10.003

Table 2. Hansen solubility parameters and other properties of the selected solvents and the classically used petrol-based solvent toluene for comparison.

Toluene cHX Phe Ani Euc
BP /°Ca 111 154 193 154 177
δD /MPa½b   18.0   17.8   18.4   17.8   16.7
δP /MPa½b     1.4     8.4     4.5     4.4     4.6
δH /MPa½b     2.0     5.1     4.0     6.9     3.4
αc     0.00     0.00     0.00     0.00     0.00
βc     0.11     0.53     0.30     0.32     0.61
π*c     0.54     0.76     0.69     0.73     0.36
VM /cm3·mol−1b 107 104 127 109 168
DNc     1     18     8     9     24
logPowa     2.7     0.86     2.0     2.6     3.4
Safety /10d     5     3     4     4     3
Health /10d     6     2     1     1     2
Environment /10d     3     5     5     5     5
a

Data obtained from REACH registration dossiers.

b

Data obtained from the HSPiP software (Abbott and Yamamoto, 2015).

c

Kamlet-Abboud-Taft solvatochromic parameters (hydrogen bond donating ability, α; hydrogen bond accepting ability, β; dipolarity/polarisability, π*) and donor number (DN) (Jessop et al., 2012; Marcus, 1993).

d

CHEM21 solvent selection rankings, with low scores preferred (Prat et al., 2016).