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. Author manuscript; available in PMC: 2024 Nov 6.
Published in final edited form as: Nature. 2023 Jul 5;619(7971):811–818. doi: 10.1038/s41586-023-06301-3

Extended Data Fig.5 |. Identification of 5’ capping for different HCV strains.

Extended Data Fig.5 |

CapZyme-seq analysis of RNA isolated from Huh7.5 cells infected with the indicated HCV genotypes/strains. Mean-difference plots show log2 (fold changes) as a function of log2 (average abundance) for reads mapping to the 5’ termini of individual RNA molecules. Enrichment with Rpp (a) and AtNUDX23 (b) was based on comparison of enzyme-treated libraries to no enzyme control libraries. The log2 (fold values) observed for HCV(+), HCV(–) and 5S rRNA (5’ppp) for the different genotypes/strains are summarized in (c) for Rpp and (d) for AtNUDX23. Data is derived from a single biological replicate. Main Fig. 2c shows replicate experiments for selected strains.