Table 1. Summary of the ADEMP Planning and Reporting Structure for Simulation Studies.
Aims | What is the aim of the study? | To evaluate the hypothesis testing and estimation characteristics of different methods for analyzing pre–post measurements |
Data-generating mechanism |
How are data sets generated? | Pre–post measurements are simulated from a bivariate normal distribution for two groups, with varying treatment effects and pre–post correlations |
Estimands and other targets |
What are the estimands and/or other targets of the study? | The null hypothesis of no effect between groups is the primary target, the treatment effect is the secondary estimand of interest |
Methods | Which methods are evaluated? | ANCOVA, change-score analysis, and post-score analysis |
Performance measures |
Which performance measures are used? | Type I error rate, power, and bias |