Figure 4.

The best-fitting life-course hypothesis selected by the least absolute shrinkage and selection operator (lasso) for the association between each adverse childhood experience and self-harm, depression and co-occurring self-harm and depression (at age 16 years) in ALSPAC and (at age 14 years) MCS, multiply imputed data. Early childhood refers to exposure between birth and 5 years of age, middle childhood refers to exposure between 6 and 10 years of age, early adolescence refers to exposure between 11 and 13 years of age and accumulation refers to cumulative exposure to the same ACE across multiple time-points in early childhood, middle childhood and adolescence