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. Author manuscript; available in PMC: 2024 Dec 5.
Published in final edited form as: Acta Biomater. 2019 Oct 31;101:544–553. doi: 10.1016/j.actbio.2019.10.033

Figure 4.

Figure 4

Proliferation and differentiation of MC3T3 pre-osteoblasts on NanoSiHA and SiHA scaffolds without (white) and with (black) adsorbed VEGF after 7 days of culture. Cell proliferation was analyzed by measuring absorbance at 450 nm by CCK-8 protocol. Cell differentiation was evaluated by measuring ALP activity which was normalized to the cell protein content. *For each material, comparisons between conditions without and with VEGF. ф Comparison between NanoSiHA and SiHA. Statistical significance: *p < 0.05, фффp < 0.005.