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. Author manuscript; available in PMC: 2024 Dec 8.
Published in final edited form as: Am J Respir Crit Care Med. 2020 Aug 15;202(4):535–548. doi: 10.1164/rccm.201906-1123OC

Figure 1. Human non-obstructed lungs contain a highly heterogeneous myeloid cell compartment.

Figure 1

Myeloid cells, purified from non-obstructed human peritumoral lung tissues (n=3), were analyzed by single-cell RNA sequencing using the Seurat package. Combined single-cell transcriptomes were analyzed. (A) t-SNE representation of cell clusters identified using unsupervised clustering. Each dot represents an individual cell. Colors represent identified clusters. (B) Heatmap of scaled expression of (log values of Unique Molecular Identifiers (UMI)) for the top 20 differentially expressed genes of each cluster (based on log fold change). (C) Signature scores (arbitrary units) of individual cells for indicated gene signatures.