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. Author manuscript; available in PMC: 2024 Dec 8.
Published in final edited form as: Nature. 2021 Mar 11;593(7857):136–141. doi: 10.1038/s41586-021-03412-7

Figure 2. E484K appearing in background of B.1.1.7 with evidence of transmission.

Figure 2

a. Representation of Spike RBM:ACE2 interface (PDB: 6M0J) with residues E484, N501 and K417 highlighted as spheres coloured by element b. Maximum likelihood phylogeny of a subset of sequences from the United Kingdom bearing the E484K mutation (green) and lineage B.1.1.7 (blue), with background sequences without RBD mutations in black. As of 11th Feb 2021, 30 sequences from the B.1.1.7 lineage (one cluster of 25 at top of phylogenetic tree) have acquired the E484K mutation (red). c. Sequence accumulation over time in GISAID for UK sequences with B.1.1.7 and E484K. RBD – receptor binding domain; NTD – N terminal domain.