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. Author manuscript; available in PMC: 2024 Dec 8.
Published in final edited form as: Nature. 2021 Mar 11;593(7857):136–141. doi: 10.1038/s41586-021-03412-7

Table 1. Kinetic analysis of human ACE2 binding to SARS-CoV-2 Wuhan-1, N501Y and N501Y/ E484K/ K417N (TM) RBDs by biolayer interferometry.

Values reported represent the global fit to the data shown in Extended Data Fig. 8.

SARS-CoV-2 RBD WT SARS-CoV-2 RBD N501Y SARS-CoV-2 RBD TM
KD (nM) hACE2 133 22 64
kon (M-1.s-1) 1.3*105 1.4*105 1.3*105
koff (s-1) 1.8*10-2 3*10-3 8.5*10-3