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Advanced bone imaging technologies. (A) Pocket of bone marrow surrounded by fluorescently labelled bone matrix (red - low HA affinity probe; green - high HA affinity probe) with DAPI (blue) stained nuclei. Adapted from [59] with permission from the American Chemical Society. (B) Evidence of probe high stability on living mice skeleton. (C) Fluorescence enhancement caused by probe unfolding when binding to bone. Adapted from [60] with permission from the American Chemical Society.
