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. Author manuscript; available in PMC: 2024 Dec 6.
Published in final edited form as: J Control Release. 2018 Feb 6;273:51–67. doi: 10.1016/j.jconrel.2018.01.021

Figure 8.

Figure 8

Physicochemical characterization and biological performance of silica-based pH-responsive nanocarriers. (A) Schematic diagram of Dex/BMP-2@chi-MSNs on osteoblast differentiation. First, BMP-2 is quickly released and then activates the downstream Smad signaling by binding to specific cell surface BMP receptors. Secondly, Dex is delivered intracellularly through a pH-responsive release within lysosomes. (B) The capping effect of chitosan in the pH-responsive release of Dex from chi-MSNs. (C) Effect of different nanocarriers formulations bMSCs ALP activity cultured (D) In vivo ectopic bone formation induced by BMP-2 and Dex with different implants after 2 and 4 weeks post-implantation. Quantitative analysis of regenerated bone volume from 3D µCT images. Adapted from [114] with reprint permission from Royal Society of Chemistry.