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. Author manuscript; available in PMC: 2024 Dec 6.
Published in final edited form as: Nat Rev Chem. 2020 Sep 15;4(11):615–634. doi: 10.1038/s41570-020-0215-y

Fig. 2. Biomimetic supramolecular peptide scaffolds enable cell adhesion and proliferation.

Fig. 2

a | Peptides can seif-assembie into biomimetic matrices that act as scaffolds to generate cell cultures. b,c | Scanning electron micrographs depict osteogenic cell viability and morphology when grown in glycosaminoglycan-mimetic peptide nanofibrils that promote biomineralization (scale bars represent 50 μm)56. b | Cells grown on sulfonated-peptide-amphiphile fibrils mimicking glycosaminoglycan sulfate. c | Cell proliferation is reduced when lauryl-VVAGE (E-PA) fibrils bearing carboxylate groups are used. This material mimics non-sulfated glycosaminoglycans. d | The cells, falsely coloured here in cyan, adhere to the self-assembled peptide nanofibrils61. e | The biocompatibility is evident from the cells extending into the peptide matrix. f | The cells can also remodel the matrix to best suit them. Parts b and c adapted with permission from REF.56, Elsevier. Parts d-f adapted with permission from REF.61, Elsevier.