Table 1. The LMC classes association with clinico-histopathological variables.
| Histopathological variables | Whole dataset n=687 (%) |
LMC classes | ||||||
|---|---|---|---|---|---|---|---|---|
| Class 1 (n=71) |
Class 2 (n=122) |
Class 3 (n= 73) |
Class 4 (n=143) |
Class 5 (n=136) |
Class 6 (n=142) |
Pa | ||
| Sex : male n (%) | 310 (45) | 39 (55) | 51 (42) | 34 (47) | 56 (39) | 55 (40) | 75 (52) | 0.07 |
| Tumor site: limbs n (%) | 289 (42) | 37 (52) | 58 (48) | 26 (36) | 58 (41) | 64 (47) | 46 (32) | 0.03 |
| Age at diagnosis (years) m(r) | 58 (18, 81) | 59 (21,76) | 59 (22,79) | 60 (20,77) | 58 (18,81) | 53 (25,76) | 59 (22,81) | 0.03 |
| Breslow thickness (mm) m(r) | 2.3 (0.3, 20) | 1.7 (0.7, 5.5) | 2.1 (0.8, 8.9) | 3.2 (0.8, 20) | 2.3 (0.3, 15) | 1.8 (0.7, 12) | 3.0 (0.8, 18) | 9 × 10-14 |
| AJCC stage (%) b I | 236 (35) | 39 (55) | 42 (35) | 11 (15) | 46 (64) | 71 (53) | 21 (19) | 6 × 10-10 |
| Ulceration (present) n (%) | 228 (33) | 16 (23) | 32 (26) | 30 (41) | 53 (37) | 38 (28) | 59 (42) | 0.01 |
| Mitotic rate (/mm2) | 1 (0,25) | 0 (0,11) | 1 (0,17) | 2 (0,25) | 1 (0,13) | 1 (0,12) | 1 (0,18) | 0.002 |
| TILs (%) Absent | 76 (15) | 2 (4) | 13 (14) | 17 (32) | 14 (16) | 15 (16) | 15 (13) | 6 × 10-4 |
| BRAF mutant yes (%) | 266 (47) | 26 (43) | 38 (30) | 23 (40) | 44 (36) | 63 (59) | 72 (61) | 6 × 10-5 |
| NRAS mutant yes (%) | 138 (25) | 8 (14) | 35 (34) | 17 (30) | 41 (34) | 20 (19) | 17 (15) | 3 × 10-4 |
a
The associations were tested using Pearson’s chi-squared test for categorical variables and the Kruskal-Wallis test for continuous variables. Symbol n is the number of samples, m is the median and r is the range.
b
7 patients had mucosal melanoma and, although they were classified, they were not included in survival analyses. Their AJCC stage was not reported. Each of LMC class 2 and 4 contained 2 of these, while class 3, 5 and 6 had 1 each.