Table 2. Types of Clinical Trial Reviews used and Approval Timelines For Candidate Vaccines against Ebola Virus Disease.
Candidate vaccine | Clinical trial phase | Target countries | Mode of review | Timeline | Trial status with references |
---|---|---|---|---|---|
GSK ChAd 3 | Phase I | Mali, UK | Individual | 2 weeks | Completed15 |
Phase II | Ghana, Nigeria, Cameroun, Mali, Senegal | Joint | 3 months | ongoing | |
Phase III | Liberia | Could not be completed | |||
Merck/Newlink r-VSV-ZEBOV | I | UK, Germany, Switzerland, Gabon, Kenya | Individual | 2-3 weeks | Completed18 |
III | Guinea | Assisted | 2 weeks | Completed19 | |
III | Sierra Leone | Completed20 | |||
J&J Ad26-ZEBOV/MVA | I | *Ghana, Kenya, Uganda, Uganda, Tanzania | Joint | 1-3 months | |
II | |||||
III | Sierra Leone | Could not be started |
Application was withdrawn because product shelf-life expired before approval.