Table 3. PAF for dementia risk factors in the Latin American sample (n=12 865).

	RR for dementia (95% CI)	Risk factor prevalence	Communality	PAF	Weighted PAF*
Early life (<45 years)
Low education	1.6 (1.3–2.0)	68.8%	36%	29.2% (28.4–30.0)	10.9% (10.4–11.5)
Midlife (45–64 years)
Hearing loss	1.9 (1.4–2.7)	28.8%	48%	20.6% (19.9–21.3)	7.7% (7.3–8.2)
Hypertension	1.6 (1.2–2.2)	55.6%	59%	25.0% (24.3–25.8)	9.3% (8.8–9.8)
Obesity	1.6 (1.3–1.9)	44.8%	53%	21.2% (20.5–21.9)	7.9% (7.5–8.4)
Later life (≥65 years)
Smoking	1.6 (1.2–2.2)	30.0%	60%	17.8% (17.2–18.5)	5.7% (5.3–6.1)
Depression	1.9 (1.6–2.3)	23.9%	55%	17.7% (17.1–18.4)	6.6% (6.2–7.0)
Physical inactivity	1.4 (1.2–1.7)	34.2%	37%	17.0% (16.4–17.7)	4.5% (4.2–4.9)
Low social contact	1.6 (1.3–1.9)	0.5%	69%	0.2% (0.1–0.3)	0.1% (0–0.2)
Diabetes	1.5 (1.3–1.8)	18.5%	35%	8.5% (8.0–8.9)	3.2% (2.9–3.5)
Overall weighted PAF	..	..	..	..	55.8% (54.9–56.7)

PAF=population attributable fraction. RR=relative risk.

^*Weighted PAF is the relative contribution of each risk factor to the overall PAF when adjusted for communality.