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. Author manuscript; available in PMC: 2024 Dec 9.
Published in final edited form as: Am J Med Genet A. 2023 Dec 29;194(5):e63472. doi: 10.1002/ajmg.a.63472

Table 3. Radiological bone parameters investigated by X-hand, BIA, and DEXA scan.

X-hand BIA DEXA
Age Sex Height
SDS
Skeletal
age
Skeletal age SDS
(compared to
calendar age)
Bone
health
index
Bone
health
index
SDS
Negative ulnar
variance,
yes/no (mm)
Ulnar variance
(mm) in healthy
individualsa
Bone mineral content (kg)
compared to
BIA reference range for
sex and age
Bone mineral
density: lumbar
vertebrae (Z-score)
Bone mineral
density: femoral
neck (Z-score)
3.0 M –1.15   2.9 –0.3 3 –1.5 No (–3.5) –2.0 ± 1.8 - -   -
4.1 F –1.12   3.3 –1.3 3.4 –1.2 Yes (–3.6) –2.1 ± 1.4     -     –2.6 –4.7
4.2 F –0.57   5.1 1.3 3.6 –1.7 Yes (–5.7) –2.1 ± 1.4     -       -   -
4.6 F –0.22   4.4 –0.5 4.2   0.0 Yes (–4.6) –2.1 ± 1.4     -   -   -
4.9 F –0.99   4.7 –0.4 3.4 –2.2 No (–3.4) –2.1 ± 1.4 -   0.2   -
5.0 F   0.07   -   -   -   - - - –0.4   -
7.5 F   0.44   8.1   0.7 4.4 –0.3 Yes (–6.1) –2.3 ± 1.3 1.4 (high)   1.1 -0.3
8.8 F   1.22 10.4   1.9 4.3 –2.8 Yes (–7.9) –2.7 ±2.5 1.4 (low)   -   -
9.5 F   0.07 11.9   2.9 4.4 –1.4 Yes (–4.8) – 1.9 ± 1.4 -   -   -
9.7 M –1.05 10.3   0.9 4.2 –1 Yes (–3.8) –1.6 ± 1.8 -   -   -
10.4 F –0.02   9.4 –0.6 4.5 –0.2 Yes (–8.0) –1.9 ± 1.5 -   -   -
11.0 F   0.00   -   -   - -   - 2.2 (high)   1.8   2.4
12.8 F –0.70 12.1 –0.5 5.3   0.1 Yes (–4.4) –1.0 ±2.0 - –0.2 –1.6
13.7 F –0.15 14.9   1.3 5.0 –1.0 No (–2.3) – 1.8 ± 1.7 2.6 (high)   -   -
15.5 F –0.17 16.4   1.0 5.9   1.3 No (–2.6) –1.0 ± 1.8 2.3 (normal)
20.0 F –0.07 17.5 N/A 5.7   0.1 Yes (–5.0) – 1.4 ± 1.2 -   -   -

Abbreviations: BIA, bioelectrical impedance analysis; DEXA, dual-energy X-ray absorptiometry; SDS, standard deviation score.

a

Matched for method, sex, and skeletal age (Kox et al., 2020).