Table 3. Clinical Trial Data vs HES APC data for the cardiovascular outcomes.

	HES APC primary diagnosis only			Diagnosis box 1−5
	Clinical trial database only	HES APC 1 only	Both	Clinical trial database only	HES APC 1-5 only4	Both4
Heart Failure	3	10	4	1	59	6
Acute Coronary Syndrome (ACS)	3	7	8	1	122	10
Thromboembolic Stroke	3	71	8	2	91	9
Other arterial embolism	23	2	0	2	4	0
Venous Thromboembolism	7	4	7	4	17	10
Any event	18	30	27	10	101	35

¹One event is on CRF, with diagnosis “Other arterial embolism”.

²One event is on CRF, diagnosis “Heart failure” (this event has both HF and ACS diagnoses within NHS boxes 1−5).

³One event is on NHS, diagnosis “Stroke”.

⁴Five events cover two diagnoses in NHS boxes 1−5, and are listed under both categories.

⁵Three are not on a trial CRF − 2 events are ACS (box 1) and HF (box 2−5); 1 event has no diagnosis (box 1) and HF and arterial embolism (box 2−5).

⁶1 on a trial CRF − 1 is HF on CRF, and HF (box 1) and ACS (box 2−5.)