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. Author manuscript; available in PMC: 2025 Mar 24.
Published in final edited form as: J Med Chem. 2025 Feb 7;68(4):4829–4847. doi: 10.1021/acs.jmedchem.4c03104

Scheme 3. Synthesis of 5b-7b.a.

Scheme 3

a Reagents & Conditions: (a) Cs2CO3, DMF, 70°C, 2 h, 54%; (b) H2, Pd/C, MeOH, rt, 2-3 h, 99%; (c) KOH, EtOH, DMF, BuOH, reflux, overnight, 56%; (d) Cs2CO3, KI, THF, reflux, 16 h, 94%; (e) LiAlH4, THF, 0°C to rt, 44%.