Figure 1.

Flowchart. A, Study design and (B) number of coagulation cascade proteins available for analysis across the 3 methods for genetic proxy selection. All 14 proteins with venous thromboembolism (VTE)–associated proxies were also captured through the proteomic approach, though some variants differed between methods (Table S6). CES indicates cardioembolic stroke; GWAS, genome-wide association study; KEGG, Kyoto Encyclopedia of Genes and Genomes; LAAS, large artery atherosclerotic stroke; MR, Mendelian randomization; SVS, small vessel stroke; and UKB, UK Biobank.