Figure 2.
Association of genetic proxies for coagulation cascade proteins with levels of circulating coagulation factors in deCODE and UK Biobank (UKB). We only visualized associations with coagulation factors that surpass the Bonferroni-corrected significance threshold accounting for all variants and proteins that were tested (P<3.6×10−5). The size of the circle represents the magnitude of the β-coefficient for association with the coagulation cascade protein, and the color represents the direction of association (red, positive; blue, negative). All effect estimates are provided in Table S7. SNP indicates single-nucleotide polymorphism.