Table 1. Clinical details of cases whose kidney biopsies were stained with C5b-9.

Case ID	Clinical summary	Consultant histopathologist biopsy report	Glomerular C5b-9
Control 1	18-year-old female with urinary protein: creatinine ratio (uPCR) of 87 and normal serum creatinine	healthy appearances	negative
Control 2	8-year-old female with Warburg syndrome and new onset nephrotic range proteinuria; chronic lung disease; healthy renal function	healthy appearances	negative
Control 3	21-year-old male with intermittent frank hematuria; healthy renal function	healthy appearances	negative
STEC HUS 1	43-year-old female with 1 day history of nausea and vomiting; upon admission, found to be anemic and thrombocytopenic with a serum creatinine of 344 μmol/L; treated with PLEX; biopsied 14 days after symptom onset; Shiga-toxin-producing E. coli documented	acute glomerular TMA	positive
STEC HUS 2	62-year-old female with 3 days history of bloody diarrhea; thrombocytopenic and anemic; PLEX started but stopped when ADAMTS13 found to be normal; kidney dialysis required and biopsied 15 days after symptom onset; Shiga toxin HUS documented	acute glomerular TMA	positive
STEC HUS 3	2-year-old male with diarrhea and found to have Shiga toxin HUS infection; kidney dialysis required upon admission; biopsied 4 months after presentation	chronic active TMA	positive
VEGF inhibitor 1	67-year-old female with AKI and proteinuria on Avastin; creatinine 468 μmol/L; proteinuria 9 g in 24 h	chronic TMA	positive
VEGF inhibitor 2	65-year-old female with nephrotic range proteinuria on Avastin for metastatic ovarian cancer	acute glomerular TMA	positive
Atypical HUS 1	4-year-old female with microangiopathic anemia and hematuria; identified with alternative complement pathway mutation (factor H mutation)	acute glomerular TMA	positive