Extended Data Table 2. Characteristics of cases and controls a) used in metagenomic and target enrichment analysis b) used in PCR analysis.
| a | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cases - metagenomic & TE sequencing analysis (n=9) |
Controls | ||||||||
| Group 1 DIAMONDS Healthy (n=13) |
P value* | Group 2 DIAMONDS HAdV infection with normal transaminases (N=12) |
P value* | ||||||
| Sex - male | 4 (44.4) | 10(76.9) | 0.19 | 7 (58.3) | 0.67 | ||||
| Age (years) | 3.9 (3.4-5.1) | 4.1 (3.6-4.8) | 0.87 | 1.4(1.1-3.1) | 0.0006 | ||||
| Recruitment period | 14 March – 20 April 2022 | 6 Nov 2020 - 6 Jul 2021 | - | 22 May 2020 - 22 Dec 2021 | - | ||||
| b | |||||||||
|
Cases – PCR (n=32) |
Controls | ||||||||
| Group 1 DIAMONDS Healthy (n=13) |
P value* | Group 2 DIAMONDS HAdV infection with normal transaminases (N=12) |
P value* | Group 3 DIAMONDS Elevated transaminases with no HAdV infection (n=33) |
P value* | Group 4 Scottish hospitalised controls (n=16) |
P value* | ||
| Sex - male | 11 (34.4) | 10(76.9) | 0.019 | 7 (58.3) | 0.18 | 17(51.5) | 0.21 | - | - |
| Age (years) † | 4.1 (2.7-5.5) | 4.1 (3.6-4.8) | 0.95 | 1.4(1.1-3.1) | 0.0002 | 10.2(7-13.6) | <0.0001 | - | - |
| Recruitment period | 14 March – 20 August 2022 | 6 Nov 2020 - 6 Jul 2021 | - | 22 May 2020 - 22 Dec 2021 | - | 9 Sep 2020 - 8 Jan 2022 | - | 12 March - 4 April 2022 | - |
*
Fisher’s Exact or chi-squared test for categorical and Mann-Whitney (two-sided) test for continuous variables.
†
Age and sex of Group 4 controls unavailable.