Table 2. The properties of different amyloid-like fibrils formed from wild-type β2m under acidic conditions in vitro, and brief details of conditions under which each fibril type forms under non-agitating conditions [29,30].
| Fibril type | Conditions | Height (nm) | Helical period (nm) | Persistence length (μm) | Length (nm) |
|---|---|---|---|---|---|
| (1) ‘Long straight’ | pH 1.5–4.0 | ≥1.7 | ≥1000 | ||
| Protofilament | Ionic strength ≤ 50 mM | ∼4–5 | – | ||
| Type I | ∼5 | 50–80 | |||
| Type II | ∼8 | 30–60 | |||
| Type III | ∼5 | 40–100 | |||
| (2) ‘Worm-like’ | pH 2.5–4.0 Ionic strength ≥ 100 mM |
∼3.5 | – | ∼0.1 | ∼150–600 |
| (3)‘Rod-like’ | pH 3.0–4.0 Ionic strength ≥ 50 mM |
∼3.5 | – | ∼0.1 | ∼20–150 |