Table 6. Changes in tear production in different animal models.

Study	DED model type and treatment route	Exosomes group	PBS/saline group	Absolute difference between exosome and PBS group	Healthy control	Absolute difference between exosome and healthy control
Tian et al., 2023*	C57BL/6 mice BAC model, topical	MSC-Exo 3.5 mm, MSC- Exo-Ce 4.5 mm	1.5 mm	2-3 mm	5.2 mm	−1.7 to −0.7 mm
Ma et al., 2023 *	C57BL/6 mice BAC model, topical	MSC-Exo 3.5 mm, MSC- Exo-AA 5.5 mm	2 mm	1.5-3.5mm	6.5 mm	−1 to −3 mm
Wang et al., 2022*	C57BL/6 mice BAC model, topical	5 mm	2.5 mm	2.5 mm	6 mm	−1mm
Guo et al., 2022	C57BL/6 mice BAC model, topical	2.663 mm	1.850 mm	0.813 mm	4.375 mm	−1.712mm
Wang et al, 2023 *	C57BL/6 mice BAC model, topical	4 mm	2 mm	2 mm	1 mm	3 mm
Yu et al., 2020	C57BL/6 mice BAC model, topical	6.10 mm	2.40 mm	3.7 mm	8.36 mm	−2.26

^*Values obtained from the graph as no absolute values given in the article