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. Author manuscript; available in PMC: 2025 Jun 1.
Published in final edited form as: Surv Ophthalmol. 2025 Jan 14;70(3):499–515. doi: 10.1016/j.survophthal.2025.01.003

Table 8. Summary of implicated miRNAs and their targeted pathways from Sjögren’s syndrome and dry eye disease studies.

Study Disease Exosomal miRNA Targeted Pathway
Xing et al.
2022		 SS miR−125b Suppression of PRDM1 regulated B cell differentiation
Zhao et al.
2023		 SS miR−125b M2-M1 macrophages imbalance, thereby affecting Th17 cells
Kim et al.
2021		 SS miR−125b M2-M1 macrophages imbalance, Th1 and Th17 cytokines
Wang et al. 2023 DED miR−125b Downregulation of NF-κB
Kim et al.
2021		 SS miR−21−5p Inhibits secretion of IL−6, IFN-γ and IL−17
Wang et al. 2023 DED miR−6873 Downregulation of NF-κB
Li et al.
2022		 SS miR−100−5p Increased polarisation of macrophages from M1 to M2 phenotype
Zhou et al.
2023		 SS miR−10A−5p Inhibits Bcl−6 and B cell differentiation