Table 4. Overall cost of AFs generation and disclosure process in the C&S GMS.
| Process | Cost across the C&S GMS |
|---|---|
| 1. Consent | £85,981 |
| 2. Genomic analysis | £1,065,261 |
| 3. Variant confirmation and interpretation | £79,773 |
| 4. Communication of results | £44,594 |
| 5. Disclosure consultations a | £87,078 |
| TOTAL | £1,362,687 |
| Cost per participant with AF panel applied (n=17,194) | £79 |
| Cost per participant with a putative AF (n=377) | £3,615 |
| Cost per new AF identified (n=157) | £8,680 |
AF = additional finding; C&S GMS = Central and South Genomic Medicine Service.
a
Disclosure-related secondary care resource use data were available for 89 of the 157 participants who received a positive AF letter, with a total cost of £49,362 (mean cost £554.63). This mean cost was applied for the 68 participants for whom disclosure-related secondary care resource use data were not available, giving a revised total cost for process 5 of £87,078