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. Author manuscript; available in PMC: 2026 Feb 4.
Published in final edited form as: Cell Rep. 2025 Feb 24;44(3):115325. doi: 10.1016/j.celrep.2025.115325

Figure 6. The computational model of RNAPI transcription predicts range of premature termination in vivo.

Figure 6

(A) Effect of premature termination (PT) on ribosome production in a model where RNAPI velocity is driven by stochastic elongation only. PT was applied across the entire transcription unit.

(B) RNAPI occupancy profiles after application of PT. Profiles are superimposed and color coded to correspond with the background in (C): black, no premature termination PT; green and orange, PT where ribosome synthesis is effective; red, ribosome synthesis is decreased (<150,000 per generation); gray, ribosome synthesis is insufficient (<100,000 per generation).

(C) Effects of PT on ribosome production in a model including stochastic elongation, RNA elements, and DNA torsion forces. PT was applied across the initial 2 kb of the transcription unit. Background colors match the color codes in (B). Since PT is applied only across a region of the transcription unit, values are significantly higher than for (A) and (C).

(D) Effect of premature termination PT on ribosome production. 10% of RNAPI can terminate prematurely without significant impairment of overall ribosome biosynthesis.