Table 3. ROC analysis and optimal CGM thresholds at 29 weeks of gestation for pregnancy outcome prediction.
Results are presented as area under the ROC analysis (95% confidence intervals). Significance levels; *P<0.05; **P<0.01, ***P<0.001.
| LGA Intergrowth | SGA Intergrowth | Preterm | NICU admission | Neonatal Hypoglycemia | |
|---|---|---|---|---|---|
| Mean CGM glucose mmol/L | |||||
| ROC results, AUC (95%CI) | 0.61 (0.52 to 0.69)* | 0.62 (0.48 to 0.76) | 0.59 (0.48 to 0.70) | 0.58 (0.46 to 0.70) | 0.57 (0.38 to 0.75) |
| Optimal threshold for sens & spec | 110 mg/dL (6.1mmol/L) |
103 mg/dL (5.7mmol/L) |
103 mg/dL (5.7mmol/L) |
115 mg/dL (6.4mmol/L) |
120 mg/dL (6.7mmol/L) |
| Sensitivity at threshold | 0.54 | 0.69 | 0.61 | 0.53 | 0.47 |
| Specificity at threshold | 0.64 | 0.57 | 0.47 | 0.63 | 0.88 |
| TIR 63-140 mg/dL; 3.5-7.8 mmol/L | |||||
| ROC results, AUC (95%CI) | 0.62 (0.53 to 0.71)** | 0.62 (0.48 to 0.76) | 0.59 (0.49 to 0.70) | 0.59 (0.48 to 0.71) | 0.61 (0.45 to 0.78) |
| Optimal threshold for sens & spec | 93.5 | 90.7 | 94.5 | 95.6 | 94.8 |
| Sensitivity at threshold | 0.56 | 0.56 | 0.63 | 0.73 | 0.71 |
| Specificity at threshold | 0.6 | 0.7 | 0.61 | 42 | 0.48 |
| TAR 63-140 mg/dL; 3.5-7.8 mmol/L | |||||
| ROC results, AUC (95%CI) | 0.61 (0.52 to 0.70)* | 0.62 (0.48 to 0.76) | 0.59 (0.48 to 0.70) | 0.61 (0.51 to 0.72)* | 0.56 (0.38 to 0.74) |
| Optimal threshold for sens & spec | 3.5 | 10.6 | 2.2 | 3.6 | 15.1 |
| Sensitivity at threshold | 0.64 | 0.44 | 0.77 | 0.64 | 0.47 |
| Specificity at threshold | 0.56 | 0.8 | 0.39 | 0.57 | 0.86 |
| TIR 63-120 mg/dL; 3.5-6.7 mmol/L | |||||
| ROC results, AUC (95%CI) | 0.61 (0.52 to 0.69)* | 0.61 (0.47 to 0.75) | 0.58 (0.47 to 0.68) | 0.59 (0.48 to 0.71) | 0.55 (0.36 to 0.73) |
| Optimal threshold for sens & spec | 80.1 | 74.2 | 81.1 | 84.9 | 58.1 |
| Sensitivity at threshold | 0.56 | 0.56 | 0.57 | 0.77 | 0.47 |
| Specificity at threshold | 0.6 | 0.72 | 0.56 | 0.44 | 0.86 |
| TAR 63-120 mg/dL; 3.5-6.7 mmol/L | |||||
| ROC results, AUC (95%CI) | 0.59 (0.51 to 0.68)* | 0.61 (0.47 to 0.75) | 0.57 (0.47 to 0.68) | 0.59 (0.48 to 0.70) | 0.54 (0.36 to 0.73) |
| Optimal threshold for sens & spec | 16.2 | 23.9 | 12.8 | 13.3 | 41.8 |
| Sensitivity at threshold | 0.61 | 0.56 | 0.73 | 0.73 | 0.47 |
| Specificity at threshold | 0.55 | 0.72 | 0.42 | 0.44 | 0.86 |
| Nocturnal mean glucose mmol/L | |||||
| ROC results, AUC (95%CI) | 0.61 (0.53 to 0.69)** | 0.63 (0.49 to 0.77) | 0.56 (0.45 to 0.67) | 0.54 (0.42 to 0.66) | 0.56 (0.39 to 0.73) |
| Optimal threshold for sens & spec | 108mg/dL (6mmol/L) |
110 mg/dL (6.1mmol/L) |
106mg/dL (5.9mmol/L) |
112mg/dL (6.2mmol/L) |
110 mg/dL (6.1mmol/L) |
| Sensitivity at threshold | 0.52 | 0.56 | 0.47 | 0.4 | 0.47 |
| Specificity at threshold | 0.75 | 0.73 | 0.69 | 0.77 | 0.75 |
| Nocturnal TIR 63-140 mg/dL; 3.5-7.8 mmol/L | |||||
| ROC results, AUC (95%CI) | 0.59 (0.50 to 0.67)* | 0.60 (0.48 to 0.72) | 0.57 (0.47 to 0.67) | 0.54 (0.43 to 0.66) | 0.56 (0.42 to 0.71) |
| Optimal threshold for sens & spec | 92.2 | 97.7 | 99.4 | 81.9 | 83.6 |
| Sensitivity at threshold | 0.44 | 0.88 | 0.97 | 0.27 | 0.35 |
| Specificity at threshold | 0.74 | 0.41 | 0.21 | 0.9 | 0.88 |
| Nocturnal TAR 63-140 mg/dL; 3.5-7.8 mmol/L | |||||
| ROC results, AUC (95%CI) | 0.64 (0.56 to 0.72)** | 0.65 (0.53 to 0.77)* | 0.58 (0.47 to 0.68) | 0.52 (0.41 to 0.64) | 0.55 (0.41 to 0.70) |
| Optimal threshold for sens & spec | 5.7 | 0.3 | 0.2 | 19.8 | 16.3 |
| Sensitivity at threshold | 0.43 | 0.81 | 0.67 | 0.2 | 0.29 |
| Specificity at threshold | 0.81 | 0.53 | 0.52 | 0.93 | 0.89 |
CGM: continuous glucose monitoring; LGA: large for gestational age; NICU: neonatal intensive care unit; ROC; receiver operating characteristic; sens & spec; sensitivity and specificity TIR: time in range; TAR: time above range; TBR: time below range;