Table 2. Summary table of participant demographics.
| AD | PD | ALS | Age- matched HC (HCo) | Young HC (HCy) | |
|---|---|---|---|---|---|
| Number | 29 | 25 | 33 | 114 | 77 |
| Mean age* (SD) | 72.1 (8.0) | 68.0 (6.0) | 62.8 (10) | 63.8 (10.4) | 46.9 (22.7) |
| Age distribution (quartile 1, quartile 3 (interquartile range) | 68.3, 78.5 (10.2) |
65.0, 72.0 (7.0) | 53.0, 70.0 (17.0) |
57.5, 70.6 (13.3) |
24.0, 69.0 (45.0) |
| % male^ | 48.3 | 60.0 | 57.6 | 57.9 | 49.3 |
| Disease score | Addenbrooke’s Cognitive Assessment (ACE) (0−100 with lower scores reflecting more cognitive impairment) | Unified Parkinson’s Disease Rating Scale – Motor score (UPDRS-Motor) (0, 108 with higher scores reflecting more severe motor impairment) | ALS Functional Rating Score – Revised (ALSFRS-R) (0–48 with lower scores reflecting more disability) | - | - |
| Mean disease score (SD) | 67.7 (12.4) | 29.8 (10.4) | 37.8 (6.3) | - | - |
| Mean years from | 4.1 (2.3) | 2.8 (1.5) | 2.0 (1.3) | - | - |
| symptom onset (SD) | |||||
| *GLM results comparing age distributions between groups: | |||||
| t-statistics | P-value (* significant) | ||||
| HCo-HCy | 7.82 | *<0.01 | |||
| HCo-PD | -1.30 | *0.05 | |||
| HCo-ALS | 0.37 | 0.55 | |||
| HCo-AD | -2.73 | *<0.01 | |||
| HCy-PD | -6.25 | *<0.01 | |||
| HCy-ALS | -5.19 | *<0.01 | |||
| HCy-AD | -7.90 | *<0.01 | |||
| PD-ALS | 1.36 | 0.12 | |||
| PD-AD | -1.03 | 0.25 | |||
| ALS-AD | -2.52 | *<0.01 | |||
^
Chi-squared test found no statistically significant difference in the proportion of males in each group: χ2 = 2.23, adjusted P-value = 1.00, degrees of freedom = 4,