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. 2020 Oct 23;44(6):2678–2690. doi: 10.3892/or.2020.7824

Figure 2.

Figure 2.

SP1 is a direct target of miR-7 in NSCLC. (A) Prediction of TargetScan; the binding sites of SP1 and miR-7 (1152–1159 and 4319–4325). (B) Luciferase reporter assays indicated that miR-7 targeted SP1 3′-UTR in A549 and SK-MES-1 cells. (C) The miR-7 expression between groups in A549 and SK-MES-1 cells after transfection with blank, miR-NC, miR-7, inhibitor-NC, or miR-7 inhibitor. (D) SP1 expression between groups in A549 and SK-MES-1 cells after transfection with miR-NC, inhibitor-NC, or blank. *P<0.05, **P<0.01 and. SP1, specific protein 1; miR-7, microRNA-7; NSCLC, non-small cell lung cancer; NC, negative control.