Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 23;44(6):2678–2690. doi: 10.3892/or.2020.7824

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Guo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 4. — miR-7 enhances radiosensitivity of NSCLC cells. (A) Clonogenic cell survival curves were generated. miR-7 overexpression decreased survival fractions of A549 cells after irradiation (SER=1.54), and inhibition of miR-7 increased the survival fraction (SER=0.89). (B and C) Cell proliferation assays revealed that miR-7-overexpressing cells had decreased viability with (B) time course (0, 24, 48 and 72 h) and (C) increasing radiation dose (0, 2, 4, 6 and 8 Gy) after 2 Gy irradiation. The 24-h time-point was selected as the representative time-point in C. (D) Wound healing (magnification, ×100) and (E) Transwell invasion (magnification, ×400) assays demonstrated that miR-7 combined with irradiation significantly inhibited the migration and invasion of NSCLC cells. *P<0.05, **P<0.01 and ***P<0.001. miR-7, microRNA-7; NSCLC, non-small cell lung cancer; SER, sensitivity enhancement ratio.