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. 2020 Oct 23;44(6):2678–2690. doi: 10.3892/or.2020.7824

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Copyright: © Guo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — miR-7 regulates TP53BP1 through SP1. The (A and B) mRNA and (C and D) protein levels of TP53BP1 in A549 and SK-MES-1 cells are higher with upregulation of SP1 or downregulation of miR-7, and are lower with downregulation of SP1 or upregulation of miR-7 compared with the negative control. (E) The correlation coefficient (Spearman's test) between SP1 and TP53BP1 in LUAD, LUSC, and lung tissue from GEPIA, revealed that SP1 was correlated with the TP53BP1 in lung cancer tissue. *P<0.05, **P<0.01. miR-7, microRNA-7; TP53BP1, tumor suppressor p53-binding protein 1; SP1, specific protein 1; LUADC, lung adenocarcinoma; LUSC, lung squamous cell carcinoma.