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. Author manuscript; available in PMC: 2021 Oct 16.
Published in final edited form as: Clin Sci (Lond). 2020 Oct 16;134(19):2535–2547. doi: 10.1042/CS20200483

Figure 1. The Renin-Angiotensin System (RAS) cascade.

Figure 1.

The renin-angiotensin system (RAS) cascade showing the sequence of events taking place during the enzymatic conversion of angiotensinogen to angiotensin-II and angiotensin-(1–7), their target receptors i.e., AT1R, AT2R and MasR, along with their physiological actions. ACE: angiotensin converting enzyme; ACE2: angiotensin converting enzyme-2; XNT: xanthenone; DIZE: diminazene aceturate; rACE2: recombinant angiotensin converting enzyme-2; AT1R: angiotensin II type 1 receptor; AT2R: angiotensin II type 2 receptor; MasR: mas receptor; SNA: sympathetic nerve activity.