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. 2020 Nov 4;18:175. doi: 10.1186/s12964-020-00607-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — The direct inhibitors of translation apparatus. The structures of compounds are derived from PubChem. BTdCPU is an activator of HRI which can phosphorylate eIF2α. Salubrinal and guanabenz are inhibitors of phosphatase and inhibit eIF2α dephosphorylation. NSC119889 and NSC119893 are direct inhibitors of eIF2-GTP-Met-tRNAi^Met ternary complex and prevent the binding of tRNAi^Met to eIF2. Hippuristanol, pateamine A and silvestrol are inhibitors of eIF4A. Elatol is an eIF4A-specific inhibitor. 4EGI-1, 4E1RCat and 4E2RCat are inhibitors of eIF4E-eIF4G association