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. 2020 Nov 4;21:500. doi: 10.1186/s12859-020-03827-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — $α / β$ Tuning for Mouse-Human Pair. The AFS w.r.t MF on Mouse-Human pair is shown. AFS is scaled along y-axis while $α$ is scaled along x-axis. Every line represents the MF scores for each value of $α$ at some specific $β$ . High value of $α$ indicates the high contribution of topological measure while high values of $β$ indicates the high contribution of sequence similarity