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. 2020 Nov 4;18:314. doi: 10.1186/s12916-020-01770-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Estimate of hazard ratio (and 95% confidence region) for different values of γ after multiple imputation. γ was set to 0 (random censoring) for all Highly Unlikely events. In this analysis, γ represents the log hazard of FoR at the time of censoring as compared to another (covariate-matched) individual that is not censored. The green line (HR) and region (95% CI) corresponds to the assumption that the hazard ratio of an FoR event was double for Possible events as compared to Unlikely events; the purple line (HR) and region (95% CI) corresponds to the assumption that the hazard ratio of an FoR event was ten times for Possible events as compared to Unlikely events