Fig. 3.

(1) For the 226 mutations, this figure shows its prevalence in CRF02_AG Nigerian patients (a), in treated CRF02_AG patients in HIVDB (b) and in treatment-naive CRF02_AG patients in HIVDB (c). NRTI DRMs are shown in blue, NNRTI DRMs are shown in purple and the remaining mutations are shown in grey. (2) 146 of the 226 mutations occurred ≥ 2 patients in CRF02_AG Nigerian patients. (3) 37 of the 226 mutations occurred significantly more frequently in CRF02_AG Nigerian patients compared to CRF02_AG treatment-naive patients in HIVDB (adjusted Fisher’s exact test p value < 0.01). Those 37 mutations are shown in this figure. NRTI nucleoside reverse transcriptase inhibitor, NNRTI non-nucleoside reverse transcriptase inhibitor, DRM drug resistant mutation, CRF circulating recombinant form, HIVDB HIV data base, RTI reverse transcriptase inhibitor