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. Author manuscript; available in PMC: 2020 Nov 4.
Published in final edited form as: J Med Chem. 2019 Oct 14;62(20):9078–9102. doi: 10.1021/acs.jmedchem.9b00623

Table 2.

Results of the Liver Histology Performed with High Dose (3 mg/kg)-Treated Mice

microvesicular steatosis necrosis
treatment positive/specimen % of specimen reported area % positive/specimen % of specimen reported area %
V/V 6/10 60 30–40 5/10 50 2–30
Aß/V 7/10 58 10–30 11/12 91 1–30
Aß/3a (3 mg/kg) 8/12 66 5–30 8/12 66 2–50
Aß/3d (3 mg/kg) 6/6 100 3–45 5/6 83 5–15
Aß/4a (3 mg/kg) 2/9 22 10–30 6/9 66 5–10
Aß/8 (3 mg/kg) 8/11 72 20–40 8/11 72 5–50