Table 2.
Improvement in BNP, RV strain, and other markers of RV function with CDH repair
| Variable | Overall (n = 460) | Pre-Op (n = 237) | After Repair* (n = 223) | Immediate Post-Op (n = 35) | Recovery (n = 188) | P Value† |
|---|---|---|---|---|---|---|
| BNP | 231 (65.1 to 671.1) | 360.7 (186.9 to 923.6) | 92.9 (23.7 to 409.6) | 498.7 (175.3 to 1,415.6) | 62 (20.7 to 282.3) | <0.0001 |
| RV GLS | −20 (−15.8 to −23.9) | −17.9 (−14.8 to −22.2) | −21.5 (−17.9 to −25) | −19.3 (−15.3 to −23.8) | −21.8 (−18.5 to −25.4) | <0.0001 |
| RV FWS | −22.6 (−18.5 to −27) | −20.5 (−16.5 to −24.4) | −24.6 (−21.1 to −28.5) | −21.9 (−17.9 to −25.3) | −25 (−21.8 to −28.8) | <0.0001 |
| RV FAC, % | 37.1 (30.5 to 44.8) | 34 (26.8 to 40.8) | 40.7 (34.2 to 48) | 35.4 (30.1 to 42.9) | 41.1 (35.2 to 48.5) | <0.0001 |
| TAPSE, cm‡ | 0.9 (0.7 to 1.1) | 0.7 (0.6 to 0.9) | 1.1 (0.9 to 1.3) | 0.9 (0.8 to 1.15) | 1.1 (0.9 to 1.3) | <0.0001 |
| TAPSEZ | −0.9 (−2.7 to 0.1) | −1.8 (−3.5 to 0.9) | −0.3 (−1.4 to 1.1) | −0.09 (−1 to 1.6) | −0.3 (−1.4 to 1.1) | <0.0001 |
| RV s’, m/s§ | 0.07 (0.06 to 0.09) | 0.06 (0.05 to 0.08) | 0.09 (0.07 to 0.1) | 0.08 (0.06 to 0.09) | 0.09 (0.08 to 0.1) | <0.0001 |
| Pulmonary hypertension | 225 (95) | 225 (95) | 118 (53) | 28 (80) | 9 (48) | <0.0001 |
Definition of abbreviations: BNP = brain-type natriuretic peptide; CDH = congenital diaphragmatic hernia; FAC = fractional area change; FWS = free-wall strain; GLS = global longitudinal strain; post-op = postoperative; pre-op = preoperative; RV = right ventricular; s’ = tricuspid annular peak systolic velocity; TAPSE = tricuspid annular plane systolic excursion; TAPSEZ = TAPSE z-score.
Continuous variables are expressed as the median (interquartile range). Categorical variables are expressed as n (%).
Includes both immediate post-op and recovery data.
P value for comparisons among the pre-op, immediate post-op, and recovery periods.
For TAPSE/TAPSEZ: overall n = 294, pre-op n = 147, post-op n = 147, immediate post-op n = 20, recovery n = 127.
For RV s’: overall n = 269, pre-op n = 134, post-op n = 135, immediate post-op n = 18, recovery n = 117.