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. 2020 Oct 1;9(5):661–668. doi: 10.1093/toxres/tfaa074

Figure 1.

Figure 1

MGMT expression and epigenetic modification changes after COEs treatment. The HBE cells were exposed to COEs weekly at doses of 1, 5, 10 μg/mL for 4 weeks, DMSO was used as vehicle control. MGMT expression levels were determined by qRT-PCR (A). The methylation of MGMT (B) and H3K36me3 modification (C) were detected by pyrosequencing and immunoblotting analysis, respectively. COEs, coke oven emissions; DMSO, Dimethyl sulfoxide; qRT-PCR, quantitative real-time PCR. *P < 0.05 compared with the DMSO group.