Table 5.

Associations between histone modification (H3K36me3) and DNA methylation (LINE-1 and MGMT)

H3K36me3 (relative %)	LINE-1 (% 5mC)		MGMT (% 5mC)
	β (95% CI)	P	β (95% CI)	P
Model 1a	−0.202(−0.036, −0.009)	0.001	−0.009 (−0.042, 0.036)	0.844
Model 2b	−0.198 (−0.036, −0.009)	0.001	−0.007 (−0.042, 0.037)	0.909
Model 3c	−0.198 (−0.036, −0.009)	0.002	−0.003 (−0.040, 0.039)	0.967

95% CI: 95% confidence intervals; 5mC, 5-methylcytosine.

^aCrude.

^bAdjusted for grilled food consumption.

^cAdjusted for grilled food consumption, age, BMI, smoking status, alcohol use, lymphocyte percentage, and white blood cell count. The variables of DNA methylation were logit transformed, while H3K36me3 was natural logarithmic transformed to improve model fit.