Table 6.
The mediation proportion by DNA damage in associations of urinary 1-OHP and epigenetic alterations
| DNA damage | Epigenetic modifications | Mediation proportion (%) [mean (95% CI)] | P |
|---|---|---|---|
| % Tail DNA | LINE-1 (% 5mC) | 33.7 (9.4, 88.0) | <0.01 |
| OTM | LINE-1 (% 5mC) | 19.2 (0.0, 59.0) | <0.05 |
| % Tail DNA | MGMT (% 5mC) | 30.5 (13.0, 57.0) | <0.001 |
| OTM | MGMT (% 5mC) | 25.7 (10.6, 49.0) | <0.001 |
| % Tail DNA | H3K36me3 (relative %) | 55.9 (26.2, 131.0) | <0.001 |
| OTM | H3K36me3 (relative %) | 34.2 (13.4, 76.0) | <0.01 |
Note: The variables of DNA methylation were logit transformed, and the other variables were natural logarithmic transformed. OTM, Olive Tail Moment; 1-OHP, 1-hydroxypyrene; 95% CI: 95% confidence intervals; 5mC, 5-methylcytosine.