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. 2020 Sep 28;127(11):1437–1455. doi: 10.1161/CIRCRESAHA.120.316770

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© 2020 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 3. — Subclustering of CD4⁺ T cells revealed 5 distinct populations. A, tSNE visualization of clustering revealed 5 distinct CD4⁺ T-cell populations. B, Dot plot of cluster-identifying genes and T-cell transcription factors. C, Violin plots of CD4.0 characterizing cytotoxic genes. D, Flow cytometry analysis of Granzyme B production by CD4⁺CD28⁻ cells on defrosted plaque samples. E, Top pathways associated with cluster CD4.0. Data shown as mean±SD (n=10; obtained from cohort 1 and 2). *P<0.05. FDR indicates false discovery rate; FOXP3, forkhead box P3; GZMK, granzyme K; IL7R, interleukin 7 receptor; KEGG, Kyoto encyclopedia of genes and genomes; LEF1, lymphoid enhancer-binding factor 1; PD1, programmed cell death protein 1;PRF1, perforin 1; TCR, T cell receptor; and tSNE, t-distributed stochastic neighbor embedding.