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. 2020 Nov 3;10:18924. doi: 10.1038/s41598-020-76033-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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POLD1^R689W-mediated sensitization of DLD-1 cells to ATR and CHK1 inhibitors in vitro. (A) Effects of ATR inhibitors (n = 3), (B) CHK1 inhibitors (n = 4), and (C) common chemotherapeutics (n = 3 for MMC and carboplatin; n = 4 for 5-FU and oxaliplatin) on the proliferation of DLD-1 POLD1^R689W/- cells as compared to POLD1^+/- and POLD1^+/+ parental and ctrl cells, measured 120 h after drug treatment. Data are presented as mean ± SEM and each data point reflects triplicate wells of multiple independently performed experiments. Asterisks (* p < 0.05, ** p < 0.01, *** p < 0.001) mark statistical significance using a two-way ANOVA with Bonferroni post-test.