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. 2020 Nov 3;10:18924. doi: 10.1038/s41598-020-76033-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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POLD1^R689W-mediated sensitization of DLD-1 cells to the ATR inhibitor AZD6738 in vivo. (A) Schematic representation of the experimental procedure. For clarity, the datasets illustrating vehicle- and AZD6738-treated POLD1^+/+ tumors (B, lower left panel) as well as vehicle- and AZD6738-treated POLD1^R689W/- tumors (B, lower right panel) are displayed separately. Error bars represent mean ± SEM of eight (vehicle-treated POLD1^R689W/- tumors) or nine mice (vehicle-treated POLD1^+/+ tumors, AZD6738-treated POLD1^+/+ tumors, and AZD6738-treated POLD1^R689W/- tumors), respectively.