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. Author manuscript; available in PMC: 2020 Nov 4.
Published in final edited form as: Mucosal Immunol. 2019 Nov 19;13(2):283–292. doi: 10.1038/s41385-019-0232-7

Table 1.

Summary of Results

Stimulus # of Functional IL-4Rα Alleles Per Cell in Smooth Muscle # of Functional IL-4Rα Alleles Per Cell in Epithelium # of Functional IL-4Rα Alleles In All Other Cell Types AHR GC Metaplasia Eosinophilia Figure # in Article
Exogenous IL-13 1 1 1 ++++ ++++++++ + 1
Exogenous IL-13 0* 1 1 ++ ++++++++ + 1
Exogenous IL-13 1 0* 1 ++ + + 1
Exogenous IL-13 0 0 1 + + + 1
Exogenous IL-13 2 2 2 ++++++++ ++++++++ + 4
House Dust 1 1 1 +++ ++++++++ ++++++++ 2,3
Mite Extract
House Dust 0 1 1 +++ ++++++++ ++++++++ 2,3
Mite Extract
House Dust 1 0 1 + + ++++++++ 2,3
Mite Extract
House Dust 0 0 1 + + ++++++++ 2,3
Mite Extract
House Dust 2 2 2 ++++++ ++++++++ ++++++++ 4,5
Mite Extract
House Dust 0 2 2 +++ ++++++++ ++++++++ 5
Mite Extract
House Dust 2 0 2 +++ + ++++++++ 5
Mite Extract
House Dust 0 0 2 + + ++++++++ 5
Mite Extract
*

“0” denotes complete genetic deletion of IL-4Rα in the great majority of the cells targeted by Cre, rather than complete genetic deletion in every Cre-targeted cell.