Table 3.
Studies researching optogenetic AF cardioversion.
| Author, year | Opsin | Light pulse characteristics | Additional remarks | Reference |
|---|---|---|---|---|
| Nyns et al., 2019 | ReaChR2 | 470 nm, 2.5 mW/mm2, 20 mm2, 1000 ms | AF termination success rate dropped with the decrease in the surface | [35] |
| Boyle et al., 2018 | ChR2 | 488 nm, 1.5 mW/mm2, 1000 ms | LGE-CMR fibrotic heart atria tachycardia computational model | [86] |
| Bruegman et al., 2018 | ChR2 | 470 nm, 0.4 mW/mm2, 1000 ms, 100 mm2 | >0.4 mW/mm2 light pulses were the most successful in AF termination Authors used epicardial illumination Reducing light pulse time reduced the cardioversion success rate |
[81] |
| Houston et al., 2018 | ChR2 | 460 nm, 0.42 mW/mm2 up to 0.79 mW/mm2, 274 mm2, 500 ms | 0.79 mW/mm2 light pulses had the highest success rate ChR2 is most active seconds after activation |
[84] |
| Feola et al., 2017 | CatCh | 470 nm, 0.3 mW/mm2, 3, 6, 12 mm, 500 ms | Conduction line block including the rotor core and at least one unexcitable edge | [83] |
| Bruegman et al., 2016 | ChR2 | 460 nm, 0.40 mW/mm2, 143 mm2 | — | [46] |
| Bingen et al., 2014 | CatCh | 470 nm, 38 μW/mm2, 500 ms | Successful AF termination using very low intensity blue light pulses in rodent atrial cardiomyocytes | [87] |