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. 2020 Apr 23;48(14):7864–7882. doi: 10.1093/nar/gkaa277

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Schematic representation of over-regulated pathway after 48 h Forskolin stimulation. The AltProts have been positioned within this pathway. The Forskolin stimulates the cAMP pathway that involves different factors such as ARIB4B, DIXDC1 and GPR82 as previously described. The cell mobility pathway seems tightly connected to the cAMP one. The tRNA modulation and the regulation of proteins synthesis are also downstream pathways of cAMP. AltProts are associated with different levels, both in the cAMP pathway and in the tRNA modulation and protein synthesis with the involvement of AltSETD1B and AltLINC00624. The RefProt SETD18 associated with AltSETD1B was described to be involved in the epigenetic control of chromatin structure and gene expression.